This paper analyzes some of the seismic indicators of physical meaning. By 1980, 14 indicators has been full-time scanning, and use the western Qilian Mountains region corresponding to earthquakes Ms ≥ 5.0. The results show that the selected value of A, AC value, A (b) value, b value, Mf values ​​and S values ​​for seismic activity analysis of synchronous exceptions, can significantly improve the Qilian Mountains, western region have reported that the earthquake rate shock, but there are omissions . And the current regional focus area anomaly time scan showed abnormal region appear simultaneously, or slightly longer period in 2012 that occurred Ms ≥ 5.0 Size Medium earthquake possible.