Ningjiang Songhua River bridge in Jilin Province, Songyuan City, seismic intensity VIII zone, structure of main bridge with four towers and single cable plane cable-stayed bridge with Low Towers structure,in the process of seismic design , using E1 and E2 two levels of fortification, E1 and E2 earthquake recurrence interval for 100years and 2000years. E1 earthquake using multi modal response spectrum method, the E2earthquake using nonlinear time-history method in seismic response analysis. Can provide reference for similar project design.